For live-related kidney donation, the current UK guidance specifies that the donor has a right to know the recipient’s HIV status. This guidance may prevent some potential recipients from asking friends or family to donate, as they do not wish them to know they are HIV positive. Currently, it is felt necessary that the donor should know the HIV status of the recipient in order to give fully informed consent to the operation. However, the specific medical details are not required (...) in order to allow for donor informed consent. This consent requires knowledge of the general expectation for survival of a graft and the specific expectation for survival of this graft in the recipient; it does not require specific knowledge of the recipient’s medical condition. (shrink)

The title of Andy Clark's book is, among other things, a reference to one of the central terms in Martin Heidegger's early work: "Dasein" (being there) is the word that Heidegger uses to refer to beings like ourselves. Clark is no Heidegger scholar, but the reference is deliberate; among the predecessors to his book he lists not only Heidegger himself, but also the American Heidegger scholar Hubert Dreyfus and the French Heideggerean phenomenologist Maurice Merleau-Ponty. This triumvirate has played an increasingly (...) important role in recent years among the "alternative" cognitive science set, owing largely to the influence of Dreyfus's 1979 book What Computers Can't Do (Cambridge, Mass.: MIT Press, 1979), which enlisted Heideggerian and Merleau-Pontean arguments in the fight against classical symbolic processing approaches to artificial intelligence. Clark's book fits squarely in this "alternative" tradition, and it is an important contribution to the existing literature. It surveys a large array of results in cognitive scientifically oriented fields ranging from robotics to developmental psychology, and it argues convincingly that these results should encourage us to embrace a radical new research paradigm in the cognitive sciences. The central claim is that mainstream cognitive scientists should, like their more revolutionary colleagues, learn to substitute for "the disembodied, atemporal intellectualist vision of mind ... the image of mind as a controller of embodied action" (p. 7). As a clear and brightly written account of this alternative movement in cognitive science, and perhaps even as a kind of mission statement for the new paradigm, Clark's book is one of the finest I have read. It is limited, however, by the fact that the interesting and well-described empirical work that forms the center of his presentation does not always provide sufficient resources for addressing the equally important philosophical problems lurking. (shrink)

When we ask what natural kinds are, there are two different things we might have in mind. The first, which I’ll call the taxonomy question, is what distinguishes a category which is a natural kind from an arbitrary class. The second, which I’ll call the ontology question, is what manner of stuff there is that realizes the category. Many philosophers have systematically conflated the two questions. The confusion is exhibited both by essentialists and by philosophers who pose their accounts in (...) terms of similarity. It also leads to misreading philosophers who do make the distinction. Distinguishing the questions allows for a more subtle understanding of both natural kinds and their underlying metaphysics. (shrink)

Some philosophers understand natural kinds to be the categories which are constraints on enquiry. In order to elaborate the metaphysics appropriate to such an account, I consider the complicated history of scurvy, citrus, and vitamin C. It may be tempting to understand these categories in a shallow way (as mere property clusters) or in a deep way (as fundamental properties). Neither approach is adequate, and the case instead calls for middle-range ontology: starting from categories which we identify in the world (...) and elaborating their structure, but not pretending to jump ahead to a complete story about fundamental being. (shrink)

Introduction 1 P. D. Magnus and Jacob Busch 1. Form-driven vs. Content-driven Arguments for Realism 8 Juha Saatsi 2. Optimism about the Pessimistic Induction 29 Sherrilyn Roush 3. Metaphysics between the Sciences and Philosophies of Science 59 Anjan Chakravartty 4. Nominalism and Inductive Generalizations 78 Jessica Pfeifer 5. Models and Scientific Representations 94 Otávio Bueno 6. The Identical Rivals Response to Underdetermination 112 Gregory Frost-Arnold and P. D. Magnus 7. Scientific Representation and the Semiotics of Pictures 131 Laura Perini 8. (...) Philosophy of the Environmental Sciences 155 Jay Odenbaugh 9. Value Judgements and the Estimation of Uncertainty in Climate Modeling 172 Justin Biddle and Eric Winsberg 10. Feminist Standpoint Empiricism: Rethinking the Terrain in Feminist Philosophy of Science 198 Kristen Intemann 11. Naturalism and the Enlightenment Ideal: Rethinking a Central Debate in the Philosophy of Social Science 226 Daniel Steel 12. New Approaches to the Division of Cognitive Labor 250 Michael Weisberg. (shrink)

The Argument from Inductive Risk (AIR) is taken to show that values are inevitably involved in making judgements or forming beliefs. After reviewing this conclusion, I pose cases which are prima facie counterexamples: the unreflective application of conventions, use of black-boxed instruments, reliance on opaque algorithms, and unskilled observation reports. These cases are counterexamples to the AIR posed in ethical terms as a matter of personal values. Nevertheless, it need not be understood in those terms. The values which load a (...) theory choice may be those of institutions or past actors. This means that the challenge of responsibly handling inductive risk is not merely an ethical issue, but is also social, political, and historical. (shrink)

P D Walsh; Value Education in a Pluralist Society, Journal of Philosophy of Education, Volume 10, Issue 1, 30 May 2006, Pages 24–33, https://doi.org/10.1111/j.1.

P D Walsh; Value Education in a Pluralist Society, Journal of Philosophy of Education, Volume 10, Issue 1, 30 May 2006, Pages 24–33, https://doi.org/10.1111/j.1.

forall x: Calgary is a full-featured textbook on formal logic. It covers key notions of logic such as consequence and validity of arguments, the syntax of truth-functional propositional logic TFL and truth-table semantics, the syntax of first-order (predicate) logic FOL with identity (first-order interpretations), symbolizing English in TFL and FOL, and Fitch-style natural deduction proof systems for both TFL and FOL. It also deals with some advanced topics such as modal logic, soundness, and functional completeness. Exercises with solutions are available. (...) It is provided in PDF (for screen reading, printing, and a special version for dyslexics), HTML, and in LaTeX source code. (shrink)

According to the standard narrative, natural kind is a technical notion that was introduced by John Stuart Mill in the 1840s and the recent craze for natural kinds, launched by Putnam and Kripke, is a continuation of that tradition. I argue that the standard narrative is mistaken. The Millian tradition of kinds was not particularly influential in the 20th-century, and the Putnam-Kripke revolution did not clearly engage with even the remnants that were left of it. The presently active tradition of (...) natural kinds is less than half a century old. Recognizing this might help us better appreciate both Mill and natural kinds. (shrink)

We show that the set of ultimately true sentences in Hartry Field's Revenge-immune solution model to the semantic paradoxes is recursively isomorphic to the set of stably true sentences obtained in Hans Herzberger's revision sequence starting from the null hypothesis. We further remark that this shows that a substantial subsystem of second-order number theory is needed to establish the semantic values of sentences in Field's relative consistency proof of his theory over the ground model of the standard natural numbers: -CA0 (...) (second-order number theory with a -comprehension axiom scheme) is insufficient. We briefly consider his claim to have produced a solution to the semantic paradoxes by introducing this conditional. We remark that the notion of a operator can be introduced in other settings. (shrink)

The accepted narrative treats John Stuart Mill’s Kinds as the historical prototype for our natural kinds, but Mill actually employs two separate notions: Kinds and natural groups. Considering these, along with the accounts of Mill’s nineteenth-century interlocutors, forces us to recognize two distinct questions. First, what marks a natural kind as worthy of inclusion in taxonomy? Second, what exists in the world that makes a category meet that criterion? Mill’s two notions offer separate answers to the two questions: natural groups (...) for taxonomy and Kinds for ontology. This distinction is ignored in many contemporary debates about natural kinds and is obscured by the standard narrative that treats our natural kinds just as a development of Mill’s Kinds. (shrink)

It is now commonly held that values play a role in scientific judgment, but many arguments for that conclusion are limited. First, many arguments do not show that values are, strictly speaking, indispensable. The role of values could in principle be filled by a random or arbitrary decision. Second, many arguments concern scientific theories and concepts which have obvious practical consequences, thus suggesting or at least leaving open the possibility that abstruse sciences without such a connection could be value-free. Third, (...) many arguments concern the role values play in inferring from evidence, thus taking evidence as given. This paper argues that these limitations do not hold in general. There are values involved in every scientific judgment. They cannot even conceivably be replaced by a coin toss, they arise as much for exotic as for practical sciences, and they are at issue as much for observation as for explicit inference. (shrink)

This discussion note addresses Caleb Hazelwood’s ‘Practice-Centered Pluralism and a Disjunctive Theory of Art’. Hazelwood advances a disjunctive definition of art on the basis of an analogy with species concept pluralism in the philosophy of biology. We recognize the analogy between species and art, we applaud attention to practice, and we are bullish on pluralism—but it is a mistake to take these as the basis for a disjunctive definition.

Some scientific categories seem to correspond to genuine features of the world and are indispensable for successful science in some domain; in short, they are natural kinds. This book gives a general account of what it is to be a natural kind and puts the account to work illuminating numerous specific examples.

Cover songs are a familiar feature of contemporary popular music. Musicians describe their own performances as covers, and audiences use the category to organize their listening and appreciation. However, until now philosophers have not had much to say about them. This book explores how to think about covers, appreciating covers, and the metaphysics of covers and songs. Along the way, it explores a range of issues raised by covers, from the question of what precisely constitutes a cover, to the history (...) and taxonomy of the category, the various relationships that hold between songs, performances, and tracks, and the appreciation and evaluation of covers. (shrink)

Although some authors hold that natural kinds are necessarily relative to disciplinary domains, many authors presume that natural kinds must be absolute, categorical features of the reality —often assuming that without even mentioning the alternative. Recognizing both possibilities, one may ask whether the difference especially matters. I argue that it does. Looking at recent arguments about natural kind realism, I argue that we can best make sense of the realism question by thinking of natural kindness as a relation that holds (...) between a category and a domain. (shrink)

If two theory formulations are merely different expressions of the same theory, then any problem of choosing between them cannot be due to the underdetermination of theories by data. So one might suspect that we need to be able to tell distinct theories from mere alternate formulations before we can say anything substantive about underdetermination, that we need to solve the problem of identical rivals before addressing the problem of underdetermination. Here I consider two possible solutions: Quine proposes that we (...) call two theories identical if they are equivalent under a reconstrual of predicates, but this would mishandle important cases. Another proposal is to defer to the particular judgements of actual scientists. Consideration of an historical episodethe alleged equivalence of wave and matrix mechanicsshows that this second proposal also fails. Nevertheless, I suggest, the original suspicion is wrong; there are ways to enquire into underdetermination without having solved the problem of identical rivals. (shrink)

We characterise explicitly the decidable predicates on integers of Infinite Time Turing machines, in terms of admissibility theory and the constructible hierarchy. We do this by pinning down $\zeta$, the least ordinal not the length of any eventual output of an Infinite Time Turing machine ; using this the Infinite Time Turing Degrees are considered, and it is shown how the jump operator coincides with the production of mastercodes for the constructible hierarchy; further that the natural ordinals associated with the (...) jump operator satisfy a Spector criterion, and correspond to the L$_\zeta$-stables. It also implies that the machines devised are "$\Sigma_2$ Complete" amongst all such other possible machines. It is shown that least upper bounds of an "eventual jump" hierarchy exist on an initial segment. (shrink)

There is a history of thinking that photographs provide a special kind of access to the objects depicted in them, beyond the access that would be provided by a painting or drawing. What is included in the photograph does not depend on the photographer’s beliefs about what is in front of the camera. This feature leads Kendall Walton to argue that photographs literally allow us to see the objects which appear in them. Current generative algorithms produce images in response to (...) users’ text prompts. Depending on the parameters, the output can resemble specific people or things which are named in the prompt. This resemblance does not depend on the user’s beliefs, so generated images are in this sense like photographs. Given this parallel, how should we think about AI-generated images? (shrink)

A critical note on Christopher Bartel and Jack M. C. Kwong, ‘Pluralism, Eliminativism, and the Definition of Art’, Estetika 58 (2021): 100–113. Art pluralism is the view that there is no single, correct account of what art is. Instead, art is understood through a plurality of art concepts and with considerations that are different for particular arts. Although avowed pluralists have retained the word ‘art’ in their discussions, it is natural to ask whether the considerations that motivate pluralism should lead (...) us to abandon art talk altogether; that is, should pluralism lead to eliminativism? This paper addresses arguments both for and against this move. We ultimately argue that pluralism allows one to retain the word ‘art’, if one wants it, but only in a loose, conversational sense. The upshot of pluralism is that talk of art in general cannot be asked to do theoretical and philosophical work. (shrink)

We analyse the extent of possible computations following Hogarth ([2004]) conducted in Malament–Hogarth (MH) spacetimes, and Etesi and Németi ([2002]) in the special subclass containing rotating Kerr black holes. Hogarth ([1994]) had shown that any arithmetic statement could be resolved in a suitable MH spacetime. Etesi and Németi ([2002]) had shown that some relations on natural numbers that are neither universal nor co-universal, can be decided in Kerr spacetimes, and had asked specifically as to the extent of computational limits there. (...) The purpose of this note is to address this question, and further show that MH spacetimes can compute far beyond the arithmetic: effectively Borel statements (so hyperarithmetic in second-order number theory, or the structure of analysis) can likewise be resolved: Theorem A. If H is any hyperarithmetic predicate on integers, then there is an MH spacetime in which any query ? n H ? can be computed. In one sense this is best possible, as there is an upper bound to computational ability in any spacetime, which is thus a universal constant of that spacetime. Theorem C. Assuming the (modest and standard) requirement that spacetime manifolds be paracompact and Hausdorff, for any spacetime there will be a countable ordinal upper bound, , on the complexity of questions in the Borel hierarchy computable in it. Introduction 1.1 History and preliminaries Hyperarithmetic Computations in MH Spacetimes 2.1 Generalising SADn regions 2.2 The complexity of questions decidable in Kerr spacetimes An Upper Bound on Computational Complexity for Each Spacetime CiteULike Connotea Del.icio.us What's this? (shrink)

There are two ways that we might respond to the underdetermination of theory by data. One response, which we can call the agnostic response, is to suspend judgment: "Where scientific standards cannot guide us, we should believe nothing". Another response, which we can call the fideist response, is to believe whatever we would like to believe: "If science cannot speak to the question, then we may believe anything without science ever contradicting us". C.S. Peirce recognized these options and suggested evading (...) the dilemma. It is a Logical Maxim, he suggests, that there could be no genuine underdetermination. This is no longer a viable option in the wake of developments in modern physics, so we must face the dilemma head on. The agnostic and fideist responses to underdetermination represent fundamentally different epistemic viewpoints. Nevertheless, the choice between them is not an unresolvable struggle between incommensurable worldviews. There are legitimate considerations tugging in each direction. Given the balance of these considerations, there should be a modest presumption of agnosticism. This may conflict with Peirce's Logical Maxim, but it preserves all that we can preserve of the Peircean motivation. (shrink)

William James’ argument against William Clifford in The Will to Believe is often understood in terms of doxastic efficacy, the power of belief to influence an outcome. Although that is one strand of James’ argument, there is another which is driven by ampliative risk. The second strand of James’ argument, when applied to scientific cases, is tantamount to what is now called the Argument from Inductive Risk. Either strand of James’ argument is sufficient to rebut Clifford's strong evidentialism and show (...) that it is sometimes permissible to believe in the absence of compelling evidence. However, the two considerations have different scope and force. Doxastic efficacy applies in only some cases but allows any values to play a role in determining belief; risk applies in all cases but only allows particular conditional values to play a role. (shrink)

It has been over two decades since Miranda Fricker labeled epistemic injustice, in which an agent is wronged in their capacity as a knower. The philosophical literature has proliferated with variants and related concepts. By considering cases in popular music, we argue that it is worth distinguishing a parallel phenomenon of art-interpretive injustice, in which an agent is wronged in their creative capacity as a possible artist. In section 1, we consider the prosecutorial use of rap lyrics in court as (...) a central case of this injustice. In section 2, we distinguish art-interpretive injustice from other categories already discussed in recent literature. In section 3, we discuss the relationship between genre discourse and identity prejudice. The case for recognizing the category of art-interpretive injustice is that it allows one to recognize a class of harms as being importantly related in ways that one would otherwise overlook. (shrink)

A small large cardinal upper bound in $V$ for proving when certain subsets of $\omega_1$ are precisely those constructible from a real is given. In the core model we find an exact equivalence in terms of the length of the mouse order; we show that $\forall B \subseteq \omega_1 \lbrack B$ is universally Baire $\Leftrightarrow B \in L\lbrack r \rbrack$ for some real $r\rbrack$ is preserved under set-sized forcing extensions if and only if there are arbitrarily large "admissibly measurable" cardinals.

The antisaccade task provides a model paradigm that sets the inhibition of a reflexively driven behaviour against the volitional control of a goal-directed behaviour. The stability and adaptability of antisaccade performance was investigated in 23 neurologically healthy individuals. Behaviour and brain function were measured using functional magnetic resonance imaging (fMRI) prior to and immediately following two weeks of daily antisaccade training. Participants performed antisaccade trials faster with no change in directional error rate following two weeks of training; however this increased (...) speed came at the cost of the spatial accuracy of the saccade (gain) which became more hypometric following training. Training on the antisaccade task resulted in increases in fMRI activity in the fronto-basal ganglia-parietal-cerebellar ocular motor network. Following training, antisaccade latency was positively associated with fMRI activity in the frontal and supplementary eye fields, anterior cingulate and intraparietal sulcus; antisaccade gain was negatively associated with fMRI activity in supplementary eye fields, anterior cingulate, intraparietal sulcus and cerebellar vermis. In sum, the results suggest that following training, larger antisaccade latency is associated with larger activity in fronto-parietal-cerebellar ocular motor regions, and smaller antisaccade gain is associated with larger activity in fronto-parietal ocular motor regions. (shrink)

One of the problems usually encountered in comparative studies on systems of thought belonging to cultures far removed in space and time is the difference in the manner in which they conceptualize their experience. This difference in conceptualization is reflected in the difference in the words and other linguistic forms adopted in articulating their experience. Studying the thought of a specific social group involves studying the concepts special and peculiar to that group through the language that mirrors their mode of (...) thinking, their peculiar conceptual categories and forms of life. These facts have to be borne in mind in any attempt to search for the ideas of the good in Buddhism from the perspective of comparative philosophy. (shrink)

Thomas Reid is often misread as defending common sense, if at all, only by relying on illicit premises about God or our natural faculties. On these theological or reliabilist misreadings, Reid makes common sense assertions where he cannot give arguments. This paper attempts to untangle Reid's defense of common sense by distinguishing four arguments: (a) the argument from madness, (b) the argument from natural faculties, (c) the argument from impotence, and (d) the argument from practical commitment. Of these, (a) and (...) (c) do rely on problematic premises that are no more secure than claims of common sense itself. Yet (b) and (d) do not. This conclusion can be established directly by considering the arguments informally, but one might still worry that there is an implicit premise in them. In order to address this concern, I reconstruct the arguments in the framework of subjective Bayesianism. The worry becomes this: Do the arguments rely on specific values for the prior probability of some premises? Reid's appeals to our prior cognitive and practical commitments do not. Rather than relying on specific probability assignments, they draw on things that are part of the Bayesian framework itself, such as the nature of observation and the connection between belief and action. Contra the theological or reliabilist readings, the defense of common sense does not require indefensible premises. (shrink)

Let κ be a cardinal, and let H κ be the class of sets of hereditary cardinality less than κ ; let τ (κ) > κ be the height of the smallest transitive admissible set containing every element of {κ}∪H κ . We show that a ZFC-definable notion of long unfoldability, a generalisation of weak compactness, implies in the core model K, that the mouse order restricted to H κ is as long as τ. (It is known that some weak (...) large cardinal property is necessary for the latter to hold.) In other terms we delimit its strength as follows: Theorem Con(ZFC+ω2-Π 1 1-Determinacy) ⇒ ⇒Con(ZFC+V=K+∃ a long unfoldable cardinal ⇒ ⇒Con(ZFC+∀X(X # exists) + ‘‘ $\forall D \subseteq \omega_1 D$ is universally Baire ⇔ ∃r∈R(D∈L(r)))’’, and this is set-generically absolute). We isolate a notion of ω-closed cardinal which is weaker than an ω1-Erd\ os cardinal, and show that this bounds the first long unfoldable: Theorem Let κ be ω -closed. Then there is a long unfoldable ł<κ. (shrink)

This is an open-access introductory logic textbook, prepared by Jonathan Ichikawa, based on P.D. Magnus's forallx. This (v2.0, July 2020) is intended as a stable, ready-for-teaching edition.

Kyle Stanford has recently claimed to offer a new challenge to scientific realism. Taking his inspiration from the familiar Pessimistic Induction (PI), Stanford proposes a New Induction (NI). Contra Anjan Chakravartty’s suggestion that the NI is a ‘red herring’, I argue that it reveals something deep and important about science. The Problem of Unconceived Alternatives, which lies at the heart of the NI, yields a richer anti-realism than the PI. It explains why science falls short when it falls short, and (...) so it might figure in the most coherent account of scientific practice. However, this best account will be antirealist in some respects and about some theories. It will not be a sweeping antirealism about all or most of science. (shrink)

In the axiomatic development of the logic of nonrelativistic quantum mechanics it is not difficult to set down certain plausible axioms which ensure that the quantum logic of propositions has the structure of an orthomodular poset. This can be done in a number of ways, for example, as in Gunson [2], Mackey [4], Piron [5], Varadarajan [7] and Zierler [8], and we summarise one of these ways in §2 below.

Experimental evidence strongly supports the view that the subdivision of organ anlagen into smaller structural units is an autonomous process. Dalcq &Pasteels' hypothesis which says that the boundaries between the different areas into which a morphogenetic field differentiates are determined by “Threshold values” in the “potential” of the field in question, is inconsistent with our present knowledge of biochemical reaction systems. Threshold values may only be used indescribing the spatial differentiation of a morphogenetic field. It is suggested that the latter (...) concept be replaced by the concept of “optimal values” in the intensity of a morphogenetic field-specific for the various chemo-differentiations characterizing the different regions into which a morphogenetic field will split up-and that each optimal value isdeterminative for the appearance of one particular differentiation within the morphogenetic field, each differentiation being formed within a certain range of intensity of the field. On the basis of the hypothesis formulated above a “virginal” morphogenetic field will necessarily differentiate into a number of smaller fields of second order, which in their turn will split up into fields of third order, etc. ” Pattern formation” may be defined as the differentiation of a morphogenetic field into an increasing number of smaller fields of higher order of qualitative different chemical and structural composition. Since differentiation of a morphogenetic field proceeds autonomously, the capacity for pattern formation is an intrinsic property of a morphogenetic field. In the light of these considerations it is suggested that a morphogenetic field action is responsible for the first differentiation of the developing embryo into regions with predominantly ectodermal, mesodermal or endodermal differentiation tendencies. The present knowledge about the characteristic pattern formation taking place in the axial mesoderm as well as in the overlying neural plate seems to be in good agreement with the implications of the present morphogenetic field concept. It is emphasized, however, that if the present morphogenetic field concept cannot be characterized further biochemically and biophysically, it will have to be replaced by another concept which can be defined more sharply and is more easily accessible to experimental analysis. Les preuves expérimentales confirment que la subdivision des ébauches des organes en unités structurelles plus petites est un processus autonome. L'hypothèse deDalcq &Pasteels disant que les bornes entre les différents domaines formées par la différenciation d'un champ morphogénétique sont déterminées par des „valeurs seuil” dans le „potentiel” du champ en question, n'est pas en harmonie avec notre connaissance actuelle des systèmes biochimiques. Des “valeurs seuil” ne peuvent être employés qu'en décrivant la différenciation spatiale d'un champ morphogénétique. On prend en considération de remplacer le concept des “valeurs seuil” par le concept des “valeurs optimales” dans l'intensité d'un champ morphogénétique. Ce seraient les valeurs spécifiques aux différenciations chimiques diverses qui caractérisent les différents domaines dans lesquels un champ morphogénétique se différencie. En outre, chaque valeur optimale serait déterminative à la formation d'une différenciation spéciale dans le champ morphogénétique, chaque différentiation se formant dans un certain trajet de l'intensité du champ. Par suite de l'hypothèse formulée ci-dessus un champ morphogénétique “virginal” va nécessairement se différencier en un nombre de champs plus petits de deuxième ordre, qui à leur tour se divisent en champs d'ordre troisième, etc.... La régionalisation peut être définie comme la différenciation d'un champ morphogénétique dans un nombre de plus en plus élevé de champs plus petits d'ordre supérieur de composition chimique et structurelle qualitativement différente. Parce que la différenciation d'un champ morphogénétique se produit de façon autonome, le pouvoir de régionalisation est une propriété intrinsique d'un champ morphogénétique. Ces considérations nous mènent à proposer que l'action d'un champ morphogénétique est responsable de la première différenciation de l'embryon en régions qui possèdent des tendences de différenciation principalement ectodermiques, mésodermiques, ou bien endodermiques. La connaissance actuelle concernant la régionalisation caractéristique qui se produit dans le mésoderme axial ainsi que dans la plaque neurale superposée paraît se conformer aux conséquences du concept de champ morphogénétique. Cependant on souligne le fait que dans le cas òu le concept actuel du champ morphogénétique ne pourra pas être plus amplement caractérisé de façon biochimique et biophysique, il faudra le remplacer par un autre concept qui puit être défini plus nettement et qui est mieux accessible à l'analyse expérimentale. Die Auffassung, dass die Aufteilung von Organanlagen in kleineren Struktureinheiten ein selbständiger Prozess ist, findet Bestätigung in den experimentellen Ergebnissen. Die Hypothese vonDalcq &Pasteels, dass die Grenzen zwischen den unterschiedenen Gebieten, in denen ein morphogenetisches Feld sich differenziert, durch “Schwellenwerte” im “Potential” des genannten Feldes bestimmt werden, ist unvereinbar mit unserem heutigen Wissen über biochemischen Reaktionssystemen. Der Gebrauch des Begriffs “Schwellenwert” ist nur gestattet bei der Beschreibung der räumlichen Differenzierung eines morphogenetischen Feldes. Statt dieses Begriffs wird der Begriff “Optimaler Wert” vorgeschlagen; Werte also in der Intensität eines morphogenetischen Feldes, optimal und spezifisch für die verschiedene Chemodifferenzierungen, welche die Gebiete kennzeichnen, in denen ein morphogenetisches Feld sich differenzieren wird. Jeder optimaler Wert soll dann das Erscheinen einer bestimmten Differenzierung innerhalb des morphogenetischen Feldes veranlassen, welche Differenzierung sich bildet innerhalb eines bestimmten Bereichs der Feldintensität. Auf Grund der obigen Hypothese wird ein “virginelles” morphogenetisches Feld zwangsläufig sich differenzieren in eine Anzahl kleinerer Feldern zweiten Grades; diese in Felder dritten Grades, usw. Musterbildung könnte definiert werden als die Differenzierung eines morphogenetischen Feldes in eine zunehmende Anzahl kleinerer Felder höheren Grades von qualitativ verschiedener chemischen und strukturellen Zusammensetzung, Weil diese Differenzierung autonom vor sich geht, ist das Vermögen zur Musterbildung eine innewohnende Eigenschaft eines morphogenetischen Feldes. Im Lichte dieser Betrachtungen ist es naheliegend anzunehmen dass eine morphogenetische Feldwirkung verantwortlich ist für die erste Differenzierung des sich entwickelnden Embryos in Gebiete überwiegend ektodermalen, mesodermalen oder entodermalen Differenzierungstendenzen. Die heutigen Kenntnisse über die charakteristische Musterbildung im axialen Teil des Mesoderms und in der überliegenden Neuralplatte scheinen in guter Übereinstimmung zu sein mit den des morphogenetischen Feldbegriffs. Dennoch wird benachdruckt, dass, falls das gegenwärtige morphogenetische Feldbegriff nicht weiter biochemisch und biophysisch gekennzeichnet werden kann, anstatt dessen ein anderer Begriff entwickelt werden muß, der schärfer definiert werden kann und besser zugänglich ist für experimentelle Analyse. (shrink)

Experimental evidence strongly supports the view that the subdivision of organ anlagen into smaller structural units is an autonomous process. Dalcq &Pasteels' hypothesis which says that the boundaries between the different areas into which a morphogenetic field differentiates are determined by “Threshold values” in the “potential” of the field in question, is inconsistent with our present knowledge of biochemical reaction systems. Threshold values may only be used indescribing the spatial differentiation of a morphogenetic field. It is suggested that the latter (...) concept be replaced by the concept of “optimal values” in the intensity of a morphogenetic field-specific for the various chemo-differentiations characterizing the different regions into which a morphogenetic field will split up-and that each optimal value isdeterminative for the appearance of one particular differentiation within the morphogenetic field, each differentiation being formed within a certain range of intensity of the field. On the basis of the hypothesis formulated above a “virginal” morphogenetic field will necessarily differentiate into a number of smaller fields of second order, which in their turn will split up into fields of third order, etc. ” Pattern formation” may be defined as the differentiation of a morphogenetic field into an increasing number of smaller fields of higher order of qualitative different chemical and structural composition. Since differentiation of a morphogenetic field proceeds autonomously, the capacity for pattern formation is an intrinsic property of a morphogenetic field. In the light of these considerations it is suggested that a morphogenetic field action is responsible for the first differentiation of the developing embryo into regions with predominantly ectodermal, mesodermal or endodermal differentiation tendencies. The present knowledge about the characteristic pattern formation taking place in the axial mesoderm as well as in the overlying neural plate seems to be in good agreement with the implications of the present morphogenetic field concept. It is emphasized, however, that if the present morphogenetic field concept cannot be characterized further biochemically and biophysically, it will have to be replaced by another concept which can be defined more sharply and is more easily accessible to experimental analysis. Les preuves expérimentales confirment que la subdivision des ébauches des organes en unités structurelles plus petites est un processus autonome. L'hypothèse deDalcq &Pasteels disant que les bornes entre les différents domaines formées par la différenciation d'un champ morphogénétique sont déterminées par des „valeurs seuil” dans le „potentiel” du champ en question, n'est pas en harmonie avec notre connaissance actuelle des systèmes biochimiques. Des “valeurs seuil” ne peuvent être employés qu'en décrivant la différenciation spatiale d'un champ morphogénétique. On prend en considération de remplacer le concept des “valeurs seuil” par le concept des “valeurs optimales” dans l'intensité d'un champ morphogénétique. Ce seraient les valeurs spécifiques aux différenciations chimiques diverses qui caractérisent les différents domaines dans lesquels un champ morphogénétique se différencie. En outre, chaque valeur optimale serait déterminative à la formation d'une différenciation spéciale dans le champ morphogénétique, chaque différentiation se formant dans un certain trajet de l'intensité du champ. Par suite de l'hypothèse formulée ci-dessus un champ morphogénétique “virginal” va nécessairement se différencier en un nombre de champs plus petits de deuxième ordre, qui à leur tour se divisent en champs d'ordre troisième, etc. ... La régionalisation peut être définie comme la différenciation d'un champ morphogénétique dans un nombre de plus en plus élevé de champs plus petits d'ordre supérieur de composition chimique et structurelle qualitativement différente. Parce que la différenciation d'un champ morphogénétique se produit de façon autonome, le pouvoir de régionalisation est une propriété intrinsique d'un champ morphogénétique. Ces considérations nous mènent à proposer que l'action d'un champ morphogénétique est responsable de la première différenciation de l'embryon en régions qui possèdent des tendences de différenciation principalement ectodermiques, mésodermiques, ou bien endodermiques. La connaissance actuelle concernant la régionalisation caractéristique qui se produit dans le mésoderme axial ainsi que dans la plaque neurale superposée paraît se conformer aux conséquences du concept de champ morphogénétique. Cependant on souligne le fait que dans le cas òu le concept actuel du champ morphogénétique ne pourra pas être plus amplement caractérisé de façon biochimique et biophysique, il faudra le remplacer par un autre concept qui puit être défini plus nettement et qui est mieux accessible à l'analyse expérimentale. Die Auffassung, dass die Aufteilung von Organanlagen in kleineren Struktureinheiten ein selbständiger Prozess ist, findet Bestätigung in den experimentellen Ergebnissen. Die Hypothese vonDalcq &Pasteels , dass die Grenzen zwischen den unterschiedenen Gebieten, in denen ein morphogenetisches Feld sich differenziert, durch “Schwellenwerte” im “Potential” des genannten Feldes bestimmt werden, ist unvereinbar mit unserem heutigen Wissen über biochemischen Reaktionssystemen. Der Gebrauch des Begriffs “Schwellenwert” ist nur gestattet bei der Beschreibung der räumlichen Differenzierung eines morphogenetischen Feldes. Statt dieses Begriffs wird der Begriff “Optimaler Wert” vorgeschlagen; Werte also in der Intensität eines morphogenetischen Feldes, optimal und spezifisch für die verschiedene Chemodifferenzierungen, welche die Gebiete kennzeichnen, in denen ein morphogenetisches Feld sich differenzieren wird. Jeder optimaler Wert soll dann das Erscheinen einer bestimmten Differenzierung innerhalb des morphogenetischen Feldes veranlassen, welche Differenzierung sich bildet innerhalb eines bestimmten Bereichs der Feldintensität. Auf Grund der obigen Hypothese wird ein “virginelles” morphogenetisches Feld zwangsläufig sich differenzieren in eine Anzahl kleinerer Feldern zweiten Grades; diese in Felder dritten Grades, usw. Musterbildung könnte definiert werden als die Differenzierung eines morphogenetischen Feldes in eine zunehmende Anzahl kleinerer Felder höheren Grades von qualitativ verschiedener chemischen und strukturellen Zusammensetzung, Weil diese Differenzierung autonom vor sich geht, ist das Vermögen zur Musterbildung eine innewohnende Eigenschaft eines morphogenetischen Feldes. Im Lichte dieser Betrachtungen ist es naheliegend anzunehmen dass eine morphogenetische Feldwirkung verantwortlich ist für die erste Differenzierung des sich entwickelnden Embryos in Gebiete überwiegend ektodermalen, mesodermalen oder entodermalen Differenzierungstendenzen. Die heutigen Kenntnisse über die charakteristische Musterbildung im axialen Teil des Mesoderms und in der überliegenden Neuralplatte scheinen in guter Übereinstimmung zu sein mit den des morphogenetischen Feldbegriffs. Dennoch wird benachdruckt, dass, falls das gegenwärtige morphogenetische Feldbegriff nicht weiter biochemisch und biophysisch gekennzeichnet werden kann, anstatt dessen ein anderer Begriff entwickelt werden muß, der schärfer definiert werden kann und besser zugänglich ist für experimentelle Analyse. (shrink)

Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

The Alagadd?pama Sutta is the 22nd discourse of the Majjhima-nik?ya of the Pali canon. In the sutta itself it is mentioned that the Buddha’s delivery of this discourse was necessitated by the need to refute a wrong view held by one of his disciples named Ari??ha. Parallel versions of the sutta are found preserved in the Chinese?gamas. The two main similes used in the sutta, those of the snake and of the raft, are referred to in the scriptures of a (...) number of non-Therav?da Buddhist traditions as well, showing that the Buddhist doctrine represented in it is early and authentic and the message contained in the sutta was considered to be extremely significant by many early Buddhist traditions. The Alagadd?pama Sutta shows the Buddha’s role as one of the earliest thinkers in the history of philosophy who engaged in a critique of the craving for metaphysics and dogma frequently exhibited in those who propound worldviews. The Buddha did not value a belief or a worldview on grounds of the logical skill with which it was constructed but on grounds of the transformative effect it could have on the character of an individual and the sense of wellbeing it could promote. There are several discourses of the Pali canon which give prominence to this aspect of the Buddha’s teaching. Among them the Brahmaj?la Sutta of the D?gha-nik?ya and the A??hakavagga of the Suttanip?ta need special mention. The Buddha is seen to have consistently avoided engagement in speculative metaphysics, pointing out that the goal of his teaching goes beyond all such engagement. The Buddha himself distinguished his own worldview as a Teaching in the Middle avoiding the common tendency of humankind to be trapped by either of the two extremes, Eternalism or Annihilationism. These distinctive standpoints of the Buddha are all seen to be amply represented in the Alagadd?pama Sutta. (shrink)

According to many philosophers, psychological explanation canlegitimately be given in terms of belief and desire, but not in termsof knowledge. To explain why someone does what they do (so the common wisdom holds) you can appeal to what they think or what they want, but not what they know. Timothy Williamson has recently argued against this view. Knowledge, Williamson insists, plays an essential role in ordinary psychological explanation.Williamson's argument works on two fronts.First, he argues against the claim that, unlike knowledge, (...) belief is``composite'' (representable as a conjunction of a narrow and a broadcondition). Belief's failure to be composite, Williamson thinks, undermines the usual motivations for psychological explanation in terms of belief rather than knowledge.Unfortunately, we claim, the motivations Williamson argues against donot depend on the claim that belief is composite, so what he saysleaves the case for a psychology of belief unscathed.Second, Williamson argues that knowledge can sometimes provide abetter explanation of action than belief can.We argue that, in the cases considered, explanations that cite beliefs(but not knowledge) are no less successful than explanations that citeknowledge. Thus, we conclude that Williamson's arguments fail both coming andgoing: they fail to undermine a psychology of belief, and they fail tomotivate a psychology of knowledge. (shrink)

The no-miracles argument and the pessimistic induction are arguably the main considerations for and against scientific realism. Recently these arguments have been accused of embodying a familiar, seductive fallacy. In each case, we are tricked by a base rate fallacy, one much-discussed in the psychological literature. In this paper we consider this accusation and use it as an explanation for why the two most prominent `wholesale' arguments in the literature seem irresolvable. Framed probabilistically, we can see very clearly why realists (...) and anti-realists have been talking past one another. We then formulate a dilemma for advocates of either argument, answer potential objections to our criticism, discuss what remains (if anything) of these two major arguments, and then speculate about a future philosophy of science freed from these two arguments. In so doing, we connect the point about base rates to the wholesale/retail distinction; we believe it hints at an answer of how to distinguish profitable from unprofitable realism debates. In short, we offer a probabilistic analysis of the feeling of ennui afflicting contemporary philosophy of science. (shrink)

Experimental evidence strongly supports the view that the subdivision of organ anlagen into smaller structural units is an autonomous process. Dalcq &Pasteels' hypothesis which says that the boundaries between the different areas into which a morphogenetic field differentiates are determined by “Threshold values” in the “potential” of the field in question, is inconsistent with our present knowledge of biochemical reaction systems. Threshold values may only be used indescribing the spatial differentiation of a morphogenetic field. It is suggested that the latter (...) concept be replaced by the concept of “optimal values” in the intensity of a morphogenetic field-specific for the various chemo-differentiations characterizing the different regions into which a morphogenetic field will split up-and that each optimal value isdeterminative for the appearance of one particular differentiation within the morphogenetic field, each differentiation being formed within a certain range of intensity of the field. On the basis of the hypothesis formulated above a “virginal” morphogenetic field will necessarily differentiate into a number of smaller fields of second order, which in their turn will split up into fields of third order, etc. ” Pattern formation” may be defined as the differentiation of a morphogenetic field into an increasing number of smaller fields of higher order of qualitative different chemical and structural composition. Since differentiation of a morphogenetic field proceeds autonomously, the capacity for pattern formation is an intrinsic property of a morphogenetic field. In the light of these considerations it is suggested that a morphogenetic field action is responsible for the first differentiation of the developing embryo into regions with predominantly ectodermal, mesodermal or endodermal differentiation tendencies. The present knowledge about the characteristic pattern formation taking place in the axial mesoderm as well as in the overlying neural plate seems to be in good agreement with the implications of the present morphogenetic field concept. It is emphasized, however, that if the present morphogenetic field concept cannot be characterized further biochemically and biophysically, it will have to be replaced by another concept which can be defined more sharply and is more easily accessible to experimental analysis. Les preuves expérimentales confirment que la subdivision des ébauches des organes en unités structurelles plus petites est un processus autonome. L'hypothèse deDalcq &Pasteels disant que les bornes entre les différents domaines formées par la différenciation d'un champ morphogénétique sont déterminées par des „valeurs seuil” dans le „potentiel” du champ en question, n'est pas en harmonie avec notre connaissance actuelle des systèmes biochimiques. Des “valeurs seuil” ne peuvent être employés qu'en décrivant la différenciation spatiale d'un champ morphogénétique. On prend en considération de remplacer le concept des “valeurs seuil” par le concept des “valeurs optimales” dans l'intensité d'un champ morphogénétique. Ce seraient les valeurs spécifiques aux différenciations chimiques diverses qui caractérisent les différents domaines dans lesquels un champ morphogénétique se différencie. En outre, chaque valeur optimale serait déterminative à la formation d'une différenciation spéciale dans le champ morphogénétique, chaque différentiation se formant dans un certain trajet de l'intensité du champ. Par suite de l'hypothèse formulée ci-dessus un champ morphogénétique “virginal” va nécessairement se différencier en un nombre de champs plus petits de deuxième ordre, qui à leur tour se divisent en champs d'ordre troisième, etc. ... La régionalisation peut être définie comme la différenciation d'un champ morphogénétique dans un nombre de plus en plus élevé de champs plus petits d'ordre supérieur de composition chimique et structurelle qualitativement différente. Parce que la différenciation d'un champ morphogénétique se produit de façon autonome, le pouvoir de régionalisation est une propriété intrinsique d'un champ morphogénétique. Ces considérations nous mènent à proposer que l'action d'un champ morphogénétique est responsable de la première différenciation de l'embryon en régions qui possèdent des tendences de différenciation principalement ectodermiques, mésodermiques, ou bien endodermiques. La connaissance actuelle concernant la régionalisation caractéristique qui se produit dans le mésoderme axial ainsi que dans la plaque neurale superposée paraît se conformer aux conséquences du concept de champ morphogénétique. Cependant on souligne le fait que dans le cas òu le concept actuel du champ morphogénétique ne pourra pas être plus amplement caractérisé de façon biochimique et biophysique, il faudra le remplacer par un autre concept qui puit être défini plus nettement et qui est mieux accessible à l'analyse expérimentale. Die Auffassung, dass die Aufteilung von Organanlagen in kleineren Struktureinheiten ein selbständiger Prozess ist, findet Bestätigung in den experimentellen Ergebnissen. Die Hypothese vonDalcq &Pasteels , dass die Grenzen zwischen den unterschiedenen Gebieten, in denen ein morphogenetisches Feld sich differenziert, durch “Schwellenwerte” im “Potential” des genannten Feldes bestimmt werden, ist unvereinbar mit unserem heutigen Wissen über biochemischen Reaktionssystemen. Der Gebrauch des Begriffs “Schwellenwert” ist nur gestattet bei der Beschreibung der räumlichen Differenzierung eines morphogenetischen Feldes. Statt dieses Begriffs wird der Begriff “Optimaler Wert” vorgeschlagen; Werte also in der Intensität eines morphogenetischen Feldes, optimal und spezifisch für die verschiedene Chemodifferenzierungen, welche die Gebiete kennzeichnen, in denen ein morphogenetisches Feld sich differenzieren wird. Jeder optimaler Wert soll dann das Erscheinen einer bestimmten Differenzierung innerhalb des morphogenetischen Feldes veranlassen, welche Differenzierung sich bildet innerhalb eines bestimmten Bereichs der Feldintensität. Auf Grund der obigen Hypothese wird ein “virginelles” morphogenetisches Feld zwangsläufig sich differenzieren in eine Anzahl kleinerer Feldern zweiten Grades; diese in Felder dritten Grades, usw. Musterbildung könnte definiert werden als die Differenzierung eines morphogenetischen Feldes in eine zunehmende Anzahl kleinerer Felder höheren Grades von qualitativ verschiedener chemischen und strukturellen Zusammensetzung, Weil diese Differenzierung autonom vor sich geht, ist das Vermögen zur Musterbildung eine innewohnende Eigenschaft eines morphogenetischen Feldes. Im Lichte dieser Betrachtungen ist es naheliegend anzunehmen dass eine morphogenetische Feldwirkung verantwortlich ist für die erste Differenzierung des sich entwickelnden Embryos in Gebiete überwiegend ektodermalen, mesodermalen oder entodermalen Differenzierungstendenzen. Die heutigen Kenntnisse über die charakteristische Musterbildung im axialen Teil des Mesoderms und in der überliegenden Neuralplatte scheinen in guter Übereinstimmung zu sein mit den des morphogenetischen Feldbegriffs. Dennoch wird benachdruckt, dass, falls das gegenwärtige morphogenetische Feldbegriff nicht weiter biochemisch und biophysisch gekennzeichnet werden kann, anstatt dessen ein anderer Begriff entwickelt werden muß, der schärfer definiert werden kann und besser zugänglich ist für experimentelle Analyse. (shrink)

We consider various concepts associated with the revision theory of truth of Gupta and Belnap. We categorize the notions definable using their theory of circular definitions as those notions universally definable over the next stable set. We give a simplified account of varied revision sequences-as a generalised algorithmic theory of truth. This enables something of a unification with the Kripkean theory of truth using supervaluation schemes.

This paper offers a general characterization of underdetermination and gives a prima facie case for the underdetermination of the topology of the universe. A survey of several philosophical approaches to the problem fails to resolve the issue: the case involves the possibility of massive reduplication, but Strawson on massive reduplication provides no help here; it is not obvious that any of the rival theories are to be preferred on grounds of simplicity; and the usual talk of empirically equivalent theories misses (...) the point entirely. (If the choice is underdetermined, then the theories are not empirically equivalent!) Yet the thought experiment is analogous to a live scientific possibility, and actual astronomy faces underdetermination of this kind. This paper concludes by suggesting how the matter can be resolved, either by localizing the underdetermination or by defeating it entirely. Introduction A brief preliminary Around the universe in 80 days Some attempts at resolving the problem 4.1 Indexicality 4.2 Simplicity 4.3 Empirical equivalence 4.4 Is this just a philosophers' fantasy? Move along... ...nothing to see here 6.1 Rules of repetition 6.2 Some possible replies Conclusion. (shrink)

In late 2014, the jazz combo Mostly Other People Do the Killing released Blue—an album that is a note-for-note remake of Miles Davis's 1959 landmark album Kind of Blue. This is a thought experiment made concrete, raising metaphysical puzzles familiar from discussion of indiscernible counterparts. It is an actual album, rather than merely a concept, and so poses the aesthetic puzzle of why one would ever actually listen to it.

Christy Mag Uidhir has recently argued (a) that there is no in principle aesthetic difference between a live performance and a recording of that performance, and (b) that the proper aesthetic object is a type which is instantiated by the performance and potentially repeatable when recordings are played back. This paper considers several objections to (a) and finds them lacking. I then consider improvised music, a subject that Mag Uidhir explicitly brackets in his discussion. Improvisation reveals problems with (b), because (...) the performance-event and the performance-type are distinct but equally proper aesthetic objects. (shrink)